Fluconazole prophylaxis did not significantly increase invasive infections or colonisation with fluconazoleresistant fungi. Fluconazole is designated chemically as 2,4difluoro. In addition to the observed documented interactions mentioned below, there is a risk of increased plasma concentration of other compounds metabolized by cyp2c9, cyp2c19 and cyp3a4 coadministered with. Fluconazole capsules 150 mg read all of this leaflet carefully before you start taking this medicine because it contains important information for you. If you have any further questions, ask your doctor, pharmacist or nurse. Fluconazole is a moderate inhibitor of cytochrome p450 cyp isoenzymes 2c9 and 3a4.
H362 aquatic acute 3 h402 aquatic chronic 3 h412 0. Pdf randomized clinical trials in systemic antifungal therapy have traditionally. Caution should be exercised and monitoring is suggested when concomitantly administering fluconazole with drugs that have narrow therapeutic windows and are substrates of the cyp3a4 substrates. Fluconazole is an antifungal medication used for a number of fungal infections. Fluconazole is a white crystalline solid which is slightly soluble in water and saline. Fluconazole is a potent inhibitor of the cytochrome p450 3a4 isoenzyme system. This includes candidiasis, blastomycosis, coccidiodomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis versicolor. Fluconazole is also a strong inhibitor of the isoenzyme cyp2c19. It is also used to prevent candidiasis in those who are at high risk such as following organ transplantation, low birth weight. It is also used to prevent candidiasis in those who are at high risk such as following organ transplantation, low birth weight babies, and those with low blood neutrophil counts. Absorcion rapida y extensa baja upp rapida y amplia distribucion lcr y otros.
Diflucan fluconazole tablets 19949 s058 diflucan fluconazole injection 19950 s062 diflucan fluconazole powder for oral suspension 20090 s042 we acknowledge receipt of your amendment dated march 4, 2014. Diflucan tablets contain 50 mg, 100 mg, 150 mg, or 200 mg of fluconazole and the following inactive ingredients. Fluconazole injection for intravenous infusion only. Fluconazole is a white crystalline solid which is slightly soluble in water and.
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